期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 117, 期 2, 页码 334-343出版社
WILEY
DOI: 10.1002/jcb.25275
关键词
Ski; AURKA; AURORA KINASE; CENTROSOME AMPLIFICATION
资金
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [1120222]
- U.S. Public Health Service Grant [CA42573]
Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it is related with cancer progression and poor prognosis. Here we show that AURKA phosphorylates in vitro the transcripcional co-repressor Ski on aminoacids Ser326 and Ser383. Phosphorylations on these aminoacids decreased Ski protein half-life. Reduced levels of Ski resulted in centrosomes amplification and multipolar spindles formation, same as AURKA overexpressing cells. Importantly, overexpression of Ski wild type, but not S326D and S383D mutants inhibited centrosome amplification and cellular transformation induced by AURKA. Altogether, these results suggest that the Ski protein is a target in the transformation pathway mediated by the AURKA oncogene. (C) 2015 Wiley Periodicals, Inc.
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