期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 19, 期 4, 页码 865-878出版社
WILEY
DOI: 10.1111/jcmm.12508
关键词
thiosemicarbazone; crystal structure; Cu(II); V(V) and Ni(II) complexes; antimicrobial activity; antiproliferative activity
资金
- National Authority for Scientific Research of Ministry of Education and Research, Bucharest, Romania (Bilateral Grant Romania-Moldova) [680/2013]
1-phenyl-3-methyl-4-benzoyl-5-pyrazolone 4-ethyl-thiosemicarbazone (HL) and its copper(II), vanadium(V) and nickel(II) complexes: [Cu(L)(Cl)]C2H5OH(1), [Cu(L)(2)]H2O (2), [Cu(L)(Br)]H2OCH3OH (3), [Cu(L)(NO3)]2C(2)H(5)OH (4), [VO2(L)]2H(2)O (5), [Ni(L)(2)]H2O (6), were synthesized and characterized. The ligand has been characterized by elemental analyses, IR, H-1 NMR and C-13 NMR spectroscopy. The tridentate nature of the ligand is evident from the IR spectra. The copper(II), vanadium(V) and nickel(II) complexes have been characterized by different physico-chemical techniques such as molar conductivity, magnetic susceptibility measurements and electronic, infrared and electron paramagnetic resonance spectral studies. The structures of the ligand and its copper(II) (2, 4), and vanadium(V) (5) complexes have been determined by single-crystal X-ray diffraction. The composition of the coordination polyhedron of the central atom in 2, 4 and 5 is different. The tetrahedral coordination geometry of Cu was found in complex 2 while in complex 4, it is square planar, in complex 5 the coordination polyhedron of the central ion is distorted square pyramid. The in vitro antibacterial activity of the complexes against Escherichia coli, Salmonella abony, Staphylococcus aureus, Bacillus cereus and the antifungal activity against Candida albicans strains was higher for the metal complexes than for free ligand. The effect of the free ligand and its metal complexes on the proliferation of HL-60 cells was tested.
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