期刊
BIOMETRIKA
卷 99, 期 2, 页码 494-501出版社
OXFORD UNIV PRESS
DOI: 10.1093/biomet/ass002
关键词
Clinical trial; Dunnett test; Familywise error rate; Treatment selection
资金
- Engineering and Physical Sciences Research Council
- National Institute for Health Research
We generalize the Dunnett test to derive efficacy and futility boundaries for a flexible multi-arm multi-stage clinical trial for a normally distributed endpoint with known variance. We show that the boundaries control the familywise error rate in the strong sense. The method is applicable for any number of treatment arms, number of stages and number of patients per treatment per stage. It can be used for a wide variety of boundary types or rules derived from alpha-spending functions. Additionally, we show how sample size can be computed under a least favourable configuration power requirement and derive formulae for expected sample sizes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据