期刊
BIOMETRIKA
卷 98, 期 2, 页码 251-271出版社
OXFORD UNIV PRESS
DOI: 10.1093/biomet/asr018
关键词
DNA copy number; False discovery rate; Grouped hypotheses; Multiple testing
资金
- US National Science Foundation
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [0906394, 0804324] Funding Source: National Science Foundation
Copy number changes, the gains and losses of chromosome segments, are a common type of genetic variation among healthy individuals as well as an important feature in tumour genomes. Microarray technology enables us to simultaneously measure, with moderate accuracy, copy number variation at more than a million chromosome locations and for hundreds of subjects. This leads to massive data sets and complicated inference problems concerning which locations are more likely to vary. In this paper we consider a relatively simple false discovery rate approach to copy number analysis. More careful parametric change-point methods can then be focused on promising regions of the genome.
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