期刊
AQUACULTURE
卷 559, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aquaculture.2022.738429
关键词
Deltamethrin; Thymol; Oxidative stress; Immunotoxicity; Apoptosis; Channa argus
资金
- China Agriculture Research System of MOF and MARA [CARS-46]
- National Natural Science Foundation of China [31372540]
Thymol-supplemented diets alleviate the oxidative stress, immunotoxicity, and apoptosis induced by deltamethrin in Channa argus through the regulation of the NF-KB/Nrf2/p53 pathway.
This study was aimed to evaluate the ameliorative effects of thymol-supplemented diets on the toxicity damage of Channa argus induced by deltamethrin (DEL). After 28 d, the results are as follows: thymol can attenuate DELinduced oxidative stress by reversing the decrease of the activities of antioxidant enzyme (SOD, CAT, GSH, GST and GSH-Px) and the increase of the MDA content in the tissues (liver and spleen), and also by reversing the decrease of the mRNA expression levels of Nrf2, Cu/Zn SOD and HO-1, and the increase of the Keap1 mRNA expression level in the tissues (liver and spleen). Thymol can attenuate DEL-induced immunotoxicity of fish by reverse the decrease of the levels of humoral immune parameters (C4, C3, IgM and LYS) in the serum, and by reversing the increase of the expression levels of NF-KB p65, TNF-alpha, IL-18, IL-8 and IL-6, and the decrease of the IL-10 expression level in the tissues (liver and spleen). Thymol can attenuate DEL-caused apoptosis reversing the increase of the expression levels of pro-apoptosis (p53, Bax and Apaf-1) and the decrease of the expression level of anti-apoptosis Bcl-2 in the tissues (liver and spleen). Therefore, this study reveals that dietary supplementation of thymol alleviates DEL-caused immunotoxicity, oxidative stress, and apoptosis of C. argus in association with the NF-KB/Nrf2/p53 pathway.
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