期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 19, 期 2, 页码 315-326出版社
WILEY
DOI: 10.1111/jcmm.12496
关键词
vasculogenic mimicry; molecular regulation; cancer stem cell; tumour-target therapy; prognosis; high aggressive tumour
资金
- Natural Science Foundation of Shandong Province [ZR2012HM095]
Vasculogenic mimicry (VM) is a brand-new tumour vascular paradigm independent of angiogenesis that describes the specific capacity of aggressive cancer cells to form vessel-like networks that provide adequate blood supply for tumour growth. A variety of molecule mechanisms and signal pathways participate in VM induction. Additionally, cancer stem cell and epithelial-mesenchymal transitions are also shown to be implicated in VM formation. As a unique perfusion way, VM is associated with tumour invasion, metastasis and poor cancer patient prognosis. Due to VM's important effects on tumour progression, more VM-related strategies are being utilized for anticancer treatment. Here, with regard to the above aspects, we make a review of advanced research on VM in cancer.
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