期刊
BIOMETRICS
卷 67, 期 3, 页码 740-749出版社
WILEY
DOI: 10.1111/j.1541-0420.2010.01503.x
关键词
Counterfactual; Cumulative treatment effect; Inverse weighting; Proportional hazards model
资金
- National Institutes of Health [2R01-DK070869]
- Health Resources and Services Administration (HRSA), U.S. Department of Health and Human Services
In epidemiologic studies of time to an event, mean lifetime is often of direct interest. We propose methods to estimate group- (e.g., treatment-) specific differences in restricted mean lifetime for studies where treatment is not randomized and lifetimes are subject to both dependent and independent censoring. The proposed methods may be viewed as a hybrid of two general approaches to accounting for confounders. Specifically, treatment-specific proportional hazards models are employed to account for baseline covariates, while inverse probability of censoring weighting is used to accommodate time-dependent predictors of censoring. The average causal effect is then obtained by averaging over differences in fitted values based on the proportional hazards models. Large-sample properties of the proposed estimators are derived and simulation studies are conducted to assess their finite-sample applicability. We apply the proposed methods to liver wait list mortality data from the Scientific Registry of Transplant Recipients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据