期刊
FEBS LETTERS
卷 465, 期 1, 页码 79-82出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(99)01724-X
关键词
forskolin; CREB; Per1; Per2; circadian rhythm
Mammalian culture cells have the potential for periodicity, since high concentrations of serum can elicit the circadian expression of clock genes in rat-1 fibroblasts. However, the mechanism by which serum affects circadian gene expression remains unclear. In the present study, we incubated rat-1 cells with forskolin and successfully induced the rhythmic expression of Per1, Per2 and dhp. In the initial step of the circadian gene expression, a marked transient induction of Per1 was observed accompanied with CREB phosphorylation, Thus the present study strongly suggests that CREB activation through the cAMP/PKA pathway is involved in the generation of circadian rhythm in rat-1 cells (C) 2000 Federation of European Biochemical Societies.
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