期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 275, 期 1, 页码 197-209出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.275.1.197
关键词
-
Ca2+ induction of a subset of cellular and viral immediate-early activation genes in lymphocytes has been previously mapped to response elements recognized by the MEF2 family of transcription factors. Here, we demonstrate that Ca2+ activation of MEF2 response elements in T lymphocytes is mediated in synergy by two Ca2+/calmodulin-dependent enzymes, the phosphatase calcineurin, and the kinase type IV/Gr (CaMKIV/Gr), which promote transcription by the MEF2 family members MEF2A and MEF2D. Calcineurin up-regulates the activity of both factors by an NFAT-dependent mechanism, while CaMKIV/Gr selectively and independently activates MEF2D. These results identify MEF2 proteins as effecters of a pathway of gene induction in T lymphocytes which integrates diverse Ca2+ activation signals and may be broadly operative in several tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据