期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 387, 期 2, 页码 179-188出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(99)00817-1
关键词
dopamine; dopamine D-2 receptor, extrastriatal; [I-123]epidepride; SPECT (single photon emission computed tomography); alpha-methyl-para-tyrosine; schizophrenia; binding, in vivo
资金
- NIMH NIH HHS [MH44866] Funding Source: Medline
The effect of endogenous dopamine on in vivo measurement of dopamine D-2 receptors in extrastriatal regions (thalamus and temporal cortex) was evaluated with single photon emission computed tomography and the high affinity ligand [I-123]epidepride by comparing the binding potential before and after acute dopamine depletion. Dopamine depletion was achieved by per-oral administration of 5.5 g/70 kg body weight alpha-methyl-para-tyrosine given in 37 h. The alpha-methyl-pam tyrosine treatment increased the binding potential significantly in the temporal cortex (13 +/- 15%, P = 0.036) but not in the thalamus (2 +/- 9%). The increase of the binding potential in the temporal cortex correlated strongly with the increase of dysphoric mood evaluated by the Positive and Negative Symptom Scale (PANSS) (rho = 0.88, P = 0.004). These results imply that [I-123]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration. (C) 2000 Elsevier Science B.V. AU rights reserved.
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