期刊
BRAIN RESEARCH
卷 852, 期 2, 页码 274-278出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(99)02096-X
关键词
zinc; Alzheimer's disease; amyloid; plaque; neurofibrillary tangle
Excess brain zinc has been implicated in Alzheimer's neuropathology. Here we evaluated that hypothesis by searching the brains of Alzheimer's patients for abnormal zinc deposits. Using histochemical methods, we found vivid Zn2+ staining in the amyloid deposits of dense-core (senile) plaques, in the amyloid angiopathy surrounding diseased blood vessels, and in the somata and dendrites of neurons showing the characteristic neurofibrillary tangles (NFT) of Alzheimer's. In contrast, brains from age-matched, non-demented subjects showed only occasional staining for Zn2+ in scattered neurons and possible plaques. A role of abnormal zinc metabolism in Alzheimer's neuropathology is suggested. (C) 2000 Elsevier Science B.V. All rights reserved.
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