期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 387, 期 2, 页码 R9-R10出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(99)00800-6
关键词
neuropeptide-Y; stress; depression
资金
- NIMH NIH HHS [MH59317] Funding Source: Medline
The effects of neuropeptide-Y were examined in the forced swim model of depression in rats. Following a 15-min preswim, four groups of rats were given three intracerebroventricular (i.c.v.) injections of neuropeptide-Y (0.5, 5, or 10 mu g) or saline over a 24-h period. Several behaviors were subsequently measured during a 5-min forced swim. Neuropeptide-Y treatment dose dependently increased swimming and decreased immobility. The pattern of results is consistent with that produced by serotonergic antidepressant drugs in this model. (C) 2000 Elsevier Science B.V. All rights reserved.
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