期刊
NEUROSCIENCE LETTERS
卷 278, 期 3, 页码 157-160出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(99)00922-2
关键词
cannabinoid; anandamide; 2-arachidonylglycerol; ischemia; hypoxia; cell culture
资金
- NINDS NIH HHS [NS35965] Funding Source: Medline
The endogenous cannabinoids (endocannabinoids) anandamide and 2-arachidonylglycerol increased cell viability in cerebral cortical neuron cultures subjected to 8 h of hypoxia and glucose deprivation, This effect was observed at nanomolar concentrations, was reproduced by a non-hydrolyzable analog of anandamide, and was unaltered by CB1 or CB2 cannabinoid receptor antagonists. Like synthetic cannabinoids, endocannabinoids can protect neurons from hypoxic injury, and may represent endogenous neuroprotective molecules in cerebral ischemia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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