期刊
NEUROSCIENCE LETTERS
卷 278, 期 3, 页码 169-172出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(99)00929-5
关键词
amyloid precursor protein; Alzheimer's disease; cerebrospinal fluid; secretase; metabolism; Western blot
Alternative cleavage of the amyloid precursor protein (APP) results in generation and secretion of both soluble APP (sAPP) and beta-amyloid (A beta). A beta is the main component of the amyloid depositions in the brains of Alzheimer's disease (AD) patients. Using Western blotting, we compared the levels of alpha-secretase cleaved sAPP, beta-secretase cleaved sAPP and total sAPP, in cerebrospinal fluid (CSF) from 13 sporadic AD patients and 13 healthy controls. Our findings show significant amounts of beta-secretase cleaved sAPP in CSF. There was no statistically significant difference in the levels of beta-secretase cleaved sAPP between AD patients and controls. The levels of alpha-secretase cleaved sAPP and total sAPP were, however, found to be significantly lower in the AD patients than in the controls. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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