期刊
NEUROSCIENCE LETTERS
卷 278, 期 3, 页码 185-188出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(99)00936-2
关键词
anti-nociceptive effect; chemonociceptive reflexes; capsaicin-sensitive; mustard oil; antidromic nerve stimulation; TT-232; octreotide; RC-160
In rats anaesthetized with urethan and pretreated with pipecuronium bromide nocifensive reaction of blood pressure elevation evoked by intraarterial capsaicin injection was inhibited over 40 min by bilateral antidromic stimulation of the sensory fibres of the sciatic nerves. Rise in blood pressure, heart rate and respiratory frequency evoked by capsaicin were markedly diminished after smearing 1% mustard oil on the acutely denervated hindpaws indicating a release of mediators with anti-nociceptive action from cutaneous nociceptors. Intravenous injection of the putative mediator somatostatin (10 mu g/kg) or its analogues RC-160 and TT-232, but not octreotide inhibited the cardiorespiratory and blood pressure responses evoked by topical cutaneous application of mustard oil or capsaicin instillation into the eye. It is concluded, that the endocrine and the anti-nociceptive effects of somatostatin are mediated through distinct receptor subtypes and therefore, TT-232, a novel heptapeptide analogue without endocrine action, is a promising analgesic compound. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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