期刊
TETRAHEDRON LETTERS
卷 41, 期 3, 页码 425-428出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(99)02076-6
关键词
benzothiazoles; regiospecificity; antitumour compounds; cyclisation
The regiospecific synthesis of a range of antitumour 2-arylbenzothiazoles substituted in the benzothiazole ring is described. In this procedure a bromine atom situated ortho to the anilide nitrogen is used to direct a regiospecific cyclisation where, in the absence of bromine, a mixture of regioisomers is produced. The chemistry described is applicable to the synthesis of 2-arylbenzothiazoles bearing both electron-withdrawing (-NO2) and electron-donating (-NH2) substituents on the aryl ring. (C) 2000 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据