期刊
BIOMETRICAL JOURNAL
卷 51, 期 2, 页码 348-357出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/bimj.200800266
关键词
Adaptive clinical trials; Combination functions; Conditional error functions; Sample size re-estimation; Two-stage methods
Adaptive clinical trials are becoming very popular because of their flexibility in allowing mid-stream changes of sample size, endpoints, populations, etc. At the same time, they have been regarded with mistrust because they can produce bizarre results in very extreme settings. Understanding the advantages and disadvantages of these rapidly developing methods is a must. This paper reviews flexible methods for sample size re-estimation when the outcome is continuous.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据