期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 57, 期 1, 页码 16-24出版社
BIRKHAUSER VERLAG AG
DOI: 10.1007/s000180050496
关键词
integrins; cell adhesion; signaling; matrix metalloproteinases; cell invasion; collagen
The integrins are a large family of heterodimeric cell adhesion receptors mediating cell-matrix and cell-cell adhesion. They seem to play a central role in cell migration and invasion and are therefore essential in processes such as healing of tissue injuries and the progression of human cancer. Integrins function in cell invasion by mediating cell movement on matrix molecules and also by regulating the expression of matrix-degrading enzymes, namely the matrix metalloproteinases. Here we review recent findings on the mechanisms by which integrins regulate matrix degradation. A novel, multistep model of integrin-guided collagen degradation is proposed.
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