期刊
FEBS LETTERS
卷 466, 期 1, 页码 143-147出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(99)01777-9
关键词
endothelial monocyte-activating polypeptide II; caspase-7; apoptosis; leukocyte recruitment
Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. (C) 2000 Federation of European Biochemical Societies.
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