期刊
BIOMETALS
卷 27, 期 1, 页码 135-141出版社
SPRINGER
DOI: 10.1007/s10534-013-9693-4
关键词
Iron; Telomere length; Quality of life; Functional status; Health status
资金
- Centers for Disease Control and Prevention (CDC)
- National Heart Lung and Blood Institute (NHLBI)
We sought to examine the relationship between elevated transferrin saturation (TS) and measures of health status (telomere length and patient-reported health-related quality of life) to assess whether elevated TS is associated with negative patient outcomes beyond increased risk for morbidity and mortality, using a cross-sectional analysis of the Hemochromatosis and Iron Overload Screening Study supplemented with assays for leukocyte telomere length in adults a parts per thousand yen25 years old (n = 669). Among individuals with elevated TS (a parts per thousand yen45 % for women and a parts per thousand yen50 % for men), who also had a usual source of care, only 5.2 % reported ever being told by a doctor that they had an elevated iron condition. In a fully adjusted general linear regression model controlling for demographic characteristics as well as health conditions associated with iron overload, elevated TS versus non-elevated TS was associated with worse general health status (60.4 vs. 63.8, P < 0.05), mental health status (76.5 vs. 82.2, P < 0.0001) and shorter telomere length (241.4 vs. 261.3, P < 0.05). Increased surveillance of elevated TS may be in order as elevated TS is associated with decreased health status and very few patients with elevated TS are aware of their condition.
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