期刊
GENE
卷 242, 期 1-2, 页码 337-345出版社
ELSEVIER
DOI: 10.1016/S0378-1119(99)00516-8
关键词
B30.2 domain; butyrophilin; immunoglobulin superfamily; signal transduction
资金
- NHLBI NIH HHS [R01 HL055321, HL55321] Funding Source: Medline
Ermap (erythroid membrane-associated protein), a gene coding for a novel transmembrane protein produced exclusively in erythroid cells, is described. It is mapped to murine Chromosome 4, 57 cM distal to the centromere. The initial cDNA clone was isolated from a day 9 murine embryonic erythroid cell cDNA library. The predicted peptide sequence suggests that ERMAP is a transmembrane protein with two extracellular immunoglobulin folds, as well as a highly conserved B30.2 domain and several phosphorylation consensus sequences in the cytoplasmic region. ERMAP shares a high homology throughout the entire peptide with butyrophilin, a glycoprotein essential for milk lipid droplet formation and release. A GFP-ERMAP fusion protein was localized to the plasma membrane and cytoplasmic vesicles in transiently transfected 293T cells. Northern blot analysis and in-situ hybridization demonstrated that Ermap expression was restricted to fetal and adult erythroid tissues. ERMAP is likely a novel adhesion/receptor molecule specific for erythroid cells. (C) 2000 Elsevier Science B.V. All rights reserved.
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