期刊
BIOMETALS
卷 24, 期 3, 页码 559-566出版社
SPRINGER
DOI: 10.1007/s10534-011-9437-2
关键词
Vibrio; Iron; TonB; TtpC
资金
- NIAID NIH HHS [R01 AI019018-28, 5R01-AI 019018, R01 AI065981, R01 AI065981-05, 5T32-AI 007472-13, R01 AI019018, 5R01-AI 065981, T32 AI007472] Funding Source: Medline
- NIGMS NIH HHS [R01 GM064600-07, R01 GM064600] Funding Source: Medline
The Vibrios are a unique group of bacteria inhabiting a vast array of aquatic environments. Many Vibrio species are capable of infecting a wide assortment of hosts. Some of these species include V. parahaemolyticus, V. alginolyticus, V. vulnificus, V. anguillarum, and V. cholerae. The ability of these organisms to utilize iron is essential in establishing both an infection in their hosts as well as surviving in the environment. Bacteria are able to sequester iron through the secretion of low molecular weight iron chelators termed siderophores. The iron-siderophore complexes are bound by specific outer membrane receptors and are brought through both the outer and inner membranes of the cell. The energy needed to drive this active transport is achieved through the TonB energy transduction system. When first elucidated in E. coli, the TonB system was shown to be a three protein complex consisting of TonB, ExbB and ExbD. Most Vibrio species carry two TonB systems. The second TonB system includes a fourth protein; TtpC, which is essential for TonB2 mediated iron transport. Some Vibrio species have been shown to carry a third TonB system that also includes a TtpC protein.
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