Palladium-mediated ring opening of hydroxycyclopropanes

[GRAPHICS] The palladium-mediated ring opening of substituted cyclopropanols has been found to take place predominantly at the less substituted CC bond. Thus, sequential application of the titanium mediated cyclopropanation of esters and the palladium mediated ring opening of the resulting cyclopropanols provides a convenient method for functionalizing monosubstituted olefins.