Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway

2-C-Methyl- D-erythritol-4-phosphate is transformed to 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol in the presence of cytidine 5'-triphosphate by a novel Escherichia coli enzyme, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, involved in the nonmevalonate pathway. (C) 2000 Elsevier Science Ltd. All rights reserved.