期刊
BRAIN RESEARCH
卷 854, 期 1-2, 页码 249-252出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(99)02303-3
关键词
periaqueductal gray; non-opioid analgesic; rostral ventromedial medulla; endogenous opioid; spinal nociceptive neuron
Microinjection of non-opioid analgesics, such as dipyrone (DIP), into the periaqueductal gray matter (PAG) in rats causes an inhibition of nociceptive circuits in the spinal cord. We have herein investigated whether this effect is mediated by opioidergic mechanisms in the rostral ventromedial medulla (RVM), which is an important relay between the PAG and the spinal cord. The responses of spinal wide-dynamic-range neurons to noxious stimulation of their receptive field (RF) were inhibited by microinjection of DIP (100 mu g/0.5 mu l) into PAG. Subsequent microinjection of naloxone (NAL; 0.5 mu g/0.5 mu l) into RVM reversed this inhibition. The present and previous results suggest that non-opioid analgesics, as well as opiates, inhibit nociception by activating descending opioidergic mechanisms in PAG and RVM. (C) 2000 Elsevier Science B.V. All rights reserved.
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