期刊
BRAIN RESEARCH
卷 854, 期 1-2, 页码 253-256出版社
ELSEVIER
DOI: 10.1016/S0006-8993(99)02300-8
关键词
ATP diphosphohydrolase; apyrase; 5 '-nucleotidase; inhibitory avoidance; long-term potentiation; memory
Considering the involvement of extracellular ATP in the memory formation, we analyzed the effect of inhibitory avoidance training on ectonucleotidase activities in synaptosomes from hippocampus, entorhinal cortex and parietal cortex. ATP diphosphohydrolase activity presented a decrease (33%) in hippocampal synaptosomes of rats sacrificed 180 min after training. Our results also showed a decrease in synaptosomal ATP diphosphohydrolase (30% and 42% for ATP and ADP, respectively) in entorhinal cortex immediately after training. These findings suggest an integrated action of ATP diphosphohydrolase from hippocampus and entorhinal cortex in the formation of inhibitory avoidance memory. (C) 2000 Elsevier Science B.V. All rights reserved.
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