期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 28, 期 3, 页码 463-499出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(99)00242-7
关键词
free radical; signal transduction; oxidative stress; antioxidants; MAP kinase; NF-kappa beta
资金
- NIA NIH HHS [AG00378] Funding Source: Medline
Reactive oxygen species are produced by all aerobic cells and are widely believed to play a pivotal role in aging as well as a number of degenerative diseases. The consequences of the generation of oxidants in cells does not appear to be Limited to promotion of deleterious effects. Alterations in oxidative metabolism have long been known to occur during differentiation and development. Experimental perturbations in cellular redox state have been shown to exert a strong impact on these processes. The discovery of specific genes and pathways affected by oxidants led to the hypothesis that reactive oxygen species serve as subcellular messengers in gene regulatory and signal transduction pathways. Additionally, antioxidants can activate numerous genes and pathways. The burgeoning growth in the number of pathways shown to be dependent on oxidation or antioxidation has accelerated during the last decade. In the discussion presented here, we provide a tabular summary of many of the redox effects on gene expression and signaling pathways that are currently known to exist.
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