期刊
BIOMETALS
卷 22, 期 2, 页码 283-288出版社
SPRINGER
DOI: 10.1007/s10534-008-9164-5
关键词
Platinum diimine complex; Photoactive; DNA binding
资金
- Natural Science Foundation of Shanxi Province [20041012]
Interaction of DNA with a novel photoactive platinum diimine compound has been studied by electronic absorption spectra, fluorescence spectra and viscosity measurements. The red light-induced DNA cleavage activity of the platinum compound has also been studied by agarose gel electrophoresis. The results suggest that the platinum compound may interact with DNA by intercalation mode. When irradiated with red light, the platinum compound can generate singlet oxygen, resulting in cleavage of DNA.
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