期刊
JOURNAL OF CELL SCIENCE
卷 129, 期 1, 页码 121-134出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.176230
关键词
Cytoskeleton; Cytolinker; Actin; Microtubule; Gas2-like; Drosophila
类别
资金
- National Cancer Institute [K01-CA163972-01]
- National Institutes of Health [5R03MH101647]
- Wellcome Trust [WT090279MA]
- Medical Research Council, UK (MRC) [U105178780]
- NATIONAL CANCER INSTITUTE [K01CA163972] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH101647] Funding Source: NIH RePORTER
- Medical Research Council [MC_UP_1201/11, MC_U105178780] Funding Source: researchfish
- MRC [MC_UP_1201/11, MC_U105178780] Funding Source: UKRI
Coordination between different cytoskeletal systems is crucial for many cell biological functions, including cell migration and mitosis, and also plays an important role during tissue morphogenesis. Proteins of the class of cytoskeletal crosslinkers, or cytolinkers, have the ability to interact with more than one cytoskeletal system at a time and are prime candidates to mediate any coordination. One such class comprises the Gas2-like proteins, combining a conserved calponin-homology-type actin-binding domain and a Gas2 domain predicted to bind microtubules (MTs). This domain combination is also found in spectraplakins, huge cytolinkers that play important roles in many tissues in both invertebrates and vertebrates. Here, we dissect the ability of the single Drosophila Gas2-like protein Pigs to interact with both actin and MT cytoskeletons, both in vitro and in vivo, and illustrate complex regulatory interactions that determine the localisation of Pigs to and its effects on the cytoskeleton.
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