期刊
TRENDS IN BIOTECHNOLOGY
卷 18, 期 2, 页码 64-77出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0167-7799(99)01402-X
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资金
- NIGMS NIH HHS [GM44836] Funding Source: Medline
- NINDS NIH HHS [NS29632] Funding Source: Medline
Photoactivatable ligands are important tools used in drug discovery and drug development. These ligands enable researchers to identify the targets of drugs, to determine the affinity and selectivity of the drug-target interaction, and to identify the binding site on the target. Examples are presented from three fundamentally different approaches: (1) photoaffinity labeling of target macromolecules; (2) photoactivation and release of 'caged' ligands; and (3) photoimmobilization of ligands onto surfaces.
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