期刊
MOLECULAR CELL
卷 5, 期 2, 页码 355-365出版社
CELL PRESS
DOI: 10.1016/S1097-2765(00)80430-X
关键词
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资金
- NIGMS NIH HHS [GM49883] Funding Source: Medline
Drosophila ISWI, a highly conserved member of the SW12/SNF2 family of ATPases, is the catalytic subunit of three chromatin-remodeling complexes: NURF, CHRAC, and ACF. To clarify the biological functions of ISWI, we generated and characterized null and dominant-negative ISWI mutations. We found that ISWI mutations affect both cell viability and gene expression during Drosophila development. ISWI mutations also cause striking alterations in the structure of the male X chromosome. The ISWI protein does not colocalize with RNA Pol II on salivary gland polytene chromosomes, suggesting a possible role for ISWI in transcriptional repression. These findings reveal novel functions for the ISWI ATPase and underscore its importance in chromatin remodeling in vivo.
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