期刊
JAPANESE JOURNAL OF PHARMACOLOGY
卷 82, 期 2, 页码 122-129出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jjp.82.122
关键词
furanocoumarins; herbal medicine; human liver microsome; cytochrome P450 3A; inhibition
To investigate the possible drug interaction with herbal medicine, furanocoumarin derivatives isolated from several Umbelliferous crude drugs were examined for their inhibitory effects on a typical human drug metabolizing enzyme, cytochrome P450 3A (CYP3A). Most furanocoumarins tested at 0.1 mM reduced microsomal testosterone 6 beta-hydroxylation as an index of CYP3A activity to less than 50% of the central. In particular, the dimer and trimer derivatives of furanocoumarins showed striking inhibition, whose potencies were similar to that of a typical CYP3A inhibitor, ketoconazole. Preincubation of dimer types of furanocoumarins increased suppression but not most of the monomer derivatives, suggesting that the inhibition on CUP3A activity was caused by at least plural mechanisms. These results raised the possibility that the furanocoumarin containing herbal medicines may alter pharmacokinetics of co-ingested drugs similar to the case with grapefruit juice.
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