期刊
JOURNAL OF PHARMACY AND PHARMACOLOGY
卷 52, 期 2, 页码 219-223出版社
ROYAL PHARMACEUTICAL SOC GREAT BRITAIN
DOI: 10.1211/0022357001773724
关键词
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Isoflavan derivatives, glabridin (1), hispaglabridin A (2), hispaglabridin B (3), 4'-O-methylglabridin (4) and 3'-hydroxy-4'-O-methylglabridin (5), isolated from Glycyrrhiza glabra, were investigated for their ability to protect liver mitochondria against oxidative stresses. Mitochondrial lipid peroxidation linked to respiratory electron transport and that induced non-enzymatically were inhibited by these isoflavans. Hispaglabridin A (2) strongly inhibited both peroxidations and 3'-hydroxy-4'-O-methylglabridin (5) was the most effective at preventing NADH-dependent peroxidation. 3'-Hydroxy-4'-O-methylglabridin (5) protected mitochondrial respiratory enzyme activities against NADPH-dependent peroxidation injury. Dihydroxyfumarate-induced mitochondrial peroxidation was also prevented by this isoflavan. Isoflavans from G. glabra were shown to be effective in protecting mitochondrial function against oxidative stresses.
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