期刊
TRENDS IN CELL BIOLOGY
卷 10, 期 2, 页码 73-80出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(99)01694-3
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- NIGMS NIH HHS [GM43825] Funding Source: Medline
Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha chemotherapeutic agents and heat cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.
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