期刊
JOURNAL OF CELL SCIENCE
卷 128, 期 17, 页码 3171-3176出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.166074
关键词
GTPase; Rab; Traffic
类别
资金
- Norwegian Cancer Society
- South-Eastern Norway Regional Health Authority
- Research Council of Norway through its Centres of Excellence funding scheme [179571]
Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to restricted membranes in a GTP-dependent manner. In this Cell Science at a Glance and the accompanying poster, we highlight the regulation of Rab GTPases by proteins that control their membrane association and activation state, and provide an overview of the cellular processes that are regulated by Rab GTPases and their effectors, including protein sorting, vesicle motility and vesicle tethering. We also discuss the physiological importance of Rab GTPases and provide examples of diseases caused by their dysfunctions.
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