期刊
JOURNAL OF BIOCHEMISTRY
卷 127, 期 2, 页码 205-209出版社
JAPANESE BIOCHEMICAL SOC
DOI: 10.1093/oxfordjournals.jbchem.a022596
关键词
hepatocytes; interleukin-1; interleukin-6; norepinephrine; stress
Non-invasive immobilization stress causes an increase in the plasma interleukin (IL)-6 level accompanied by increased IL-6 mRNA expression and IL-6 immunoactivity in the liver [Biochem. Biophys. Res. Commun, (1997) 238, 707-711]. In the present study, using rat primary cultured hepatocytes and non-parenchymal liver cells, the effect of norepinephrine (NE) on IL-6 mRNA expression was determined. IL-6 mRNA expression in hepatocytes, but not in non-parenchymal liver cells, increased when the cells were treated with NE, The stimulatory effect of NE was inhibited by the combined use of alpha-and beta-adrenergic antagonists. IL-6 mRNA expression in hepatocytes also increased on incubation with the culture medium of non-parenchymal liver cells treated with NE, The effect of the medium was blocked by an IL-1 receptor antagonist. Moreover, exogenous IL-1 beta stimulated IL-6 mRNA expression in hepatocytes. IL-1 beta was present in the medium of non-parenchymal liver cells and increased with NE-treatment. These results suggest that NE released from sympathetic nerve terminals during stress can directly increase ILS mRNA expression in hepatocytes and indirectly through IL-1 beta production from non-parenchymal liver cells.
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