期刊
MECHANISMS OF DEVELOPMENT
卷 90, 期 2, 页码 275-278出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(99)00238-5
关键词
hyaluronan synthesis; early development; morphogenesis; hyaluronan distribution
The localization of hyaluronan has been determined in tailbud stage embryos of Xenopus laevis using a neurocan-alkaline phosphatase fusion protein. This polysaccharide was located between the germ layers and enriched in mesenchyme, the lumen of the neural tube, the embryonic gut, the hepatic cavity and the heart. A full-length cDNA for a hyaluronan synthase, Xhas2 has been cloned, The expression pattern of Xhas1 and 2 is closely similar to the distribution of hyaluronan in the embryo. Xhas1 produces hyaluronan with a molecular mass of around 40-200 kDa, while the product formed by Xhas2 has a molecular mass above 1 million Da. (C) 2000 Elsevier Science Ireland Ltd. AU rights reserved.
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