期刊
JOURNAL OF INFECTIOUS DISEASES
卷 181, 期 2, 页码 774-778出版社
UNIV CHICAGO PRESS
DOI: 10.1086/315258
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资金
- NIAID NIH HHS [AI-29549] Funding Source: Medline
- NIDDK NIH HHS [DK-51406] Funding Source: Medline
Escherichia coli FimH adhesin mediates binding to the bladder mucosa. In mice, a FimH vaccine protects against bacterial challenge. In this study, 4 monkeys were inoculated with 100 mu g of FimCH adhesin-chaperone complex mixed with MF59 adjuvant, and 4 monkeys were given adjuvant only intramuscularly. After 2 doses (day 0 and week 4), a booster at 48 weeks elicited a strong IgG antibody response to FimH in the vaccinated monkeys, All 8 monkeys were challenged with 1 mL of 10(8) E. coli cystitis isolate NU14. Three of the 4 vaccinated monkeys were protected from bacteruria and pyuria; all control monkeys were infected. These findings suggest that a vaccine based on the FimH adhesin of E. coli type 1 pill may have utility in preventing cystitis in humans.
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