期刊
SEMINARS IN IMMUNOLOGY
卷 12, 期 1, 页码 75-84出版社
ACADEMIC PRESS LTD
DOI: 10.1006/smim.2000.0209
关键词
catalysis; classification; diseases; protein tyrosine phosphatase (PTP); regulation; subcellular localization
类别
资金
- NCI NIH HHS [CA09676] Funding Source: Medline
Protein tyrosine phosphatases (PTPs) are a family of enzymes that modulate the cellular level of tyrosine phosphorylation. Based on cellular location, they are classified as receptor like or intracellular PTPs. Structure and function studies have led to the understanding of the enzymatic mechanism of this class of enzymes. Proper targeting of PTPs is essential for many cellular signalling events including antigen induced proliferative responses of B and T cells. The physiological significance of PTPs is further unveiled through mice gene knockout studies and human genome sequencing and mapping projects. Several PTPs are shown to be critical in the pathogenesis of human diseases.
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