期刊
TISSUE ANTIGENS
卷 55, 期 2, 页码 128-139出版社
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1399-0039.2000.550204.x
关键词
Ainu; Amerindians; haplotype; HLA; Japanese; Jomonese; Native Americans
The Ainu people are assumed to Ix the descendants of pre-agricultural native populations of northern Japan, while the majority of population of present-day Japan (Hondo.Japanese) is considered to have descended mainly from post-neolithic migrants. Sequence-level polymorphisms of the HLA-class I (HLA-A and HLA-B) genes were investigated in DNA samples of 50 Ainu living in Hidaka district, Hokkaido. HLA-A*2402, A*0201, A*0206. A*2601, A*3101. B*1501, B*5101, B*3901, and B*3501 were observed at frequencies of more than 10% and most of these have previously been found in populations of not only Asians but also North and South American Indians. A*68012 which has not so far been detected in Hondo-Japanese, was found in the Ainu (3%). On the other hand, several alleles common in Hondo-Japanese. including HLA-A*3303, A*1101, B*4403, B*5201, B*5401, B*4601, and B*0702 were infrequent in Ainu (0-1%). Correspondence and neighbor-joining analyses of various populations based on HLA-A, -B and -DRB1 gene frequencies enabled distinction between Asian, Native South American, European, and African populations. The Ainu, as well as Tlingit (Na-Dene), were placed midway between other East Asians. including Hondo Japanese. and Native South Americans (Americans) in the correspondence analysis. Furthermore, several HLA-A-B and HLA-B DR-DQ haplotypes common in the Ainu, are shared with some Native American populations. These observations strongly suggest a unique place for the Ainu as descendants of some Upper Paleolithic populations of East Asia, from whom some Native Americans may have descended.
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