期刊
PSYCHOPHARMACOLOGY
卷 148, 期 2, 页码 196-200出版社
SPRINGER VERLAG
DOI: 10.1007/s002130050042
关键词
cocaine; intravenous reinstatement; self-administration; sex difference of drug abuse
资金
- NIDA NIH HHS [R37 DA03240, F31 DA05915] Funding Source: Medline
Rationale: Results obtained with both humans and animals suggest that rates of relapse, or levels of reinstatement responding, may differ between males and females. However, the results obtained with humans are equivocal, and few studies have compared male and female animals on reinstatement responding. Objectives: The present experiment was designed to compare male (n=8) and female (n=8) rats on reinstatement of extinguished cocaine-reinforced responding. Methods: Rein-statement of responding was examined using a priming model in which lever pressing for cocaine (0.2 mg/kg) was extinguished by replacing cocaine infusions (2 h) with saline infusions (5 h). After responding extinguished during hour 3, reinstatement of responding was tested by administering: one of several priming injections of cocaine (0.32, 1.0 and 3.2 mg/kg) or an equal volume of saline. Results: Although males and females did not differ in the number of saline infusions self-administered after either saline or 0.32 mg/kg cocaine-priming injections, female rats self-administered significantly more saline infusions than males after In mg/kg and 3.2 mg/kg cocaine-priming injections. Additionally, the effects of 0.32 mg/kg cocaine-priming injections were significantly different from those of saline-priming injections for female, but not male, rats. There was no significant difference between males and females in total cocaine self-administered during hours 1 and 2. Conclusions: These findings indicate that female rats are more sensitive than males during the reinstatement phase of drug abuse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据