期刊
HUMAN REPRODUCTION
卷 15, 期 2, 页码 452-457出版社
OXFORD UNIV PRESS
DOI: 10.1093/humrep/15.2.452
关键词
birth weight; intergenerational trends; intrauterine constraint; Macaca mulatta; reproductive health
资金
- NIMH NIH HHS [MH 41659, MH 11579-02] Funding Source: Medline
The gestational experience of a mother can influence the intrauterine environment she pro,ides her own offspring, allowing prenatal events to affect pregnancy outcomes across several generations. Using a multigenerational database, we determined the reproductive consequences for rhesus monkeys descended from small-for-date and large-for-date birth weight matrilines, Both the maternal half-brothers and -sisters of large-for-date infants exhibited enhanced fetal growth, but for small-for-date probands, only the maternal half-sisters experienced significant intrauterine growth constraint In addition, the growth-restricted females were at higher risk of poor reproductive outcomes in adulthood, and they perpetuated the matrilineal birth weight pattern by selectively constraining the fetal development of their daughters, Collectively, these findings suggest a mechanism for the intergenerational persistence of suboptimal pregnancy outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据