期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 10, 期 1, 页码 138-145出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(99)00047-1
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Recent studies have made progress in characterizing the determinants of critical periods for experience-dependent plasticity. They highlight the role of neurotrophins, NMDA receptors and GABAergic inhibition. In particular, genetic manipulation of a single molecule, brain-derived neurotrophic factor (BDNF), has been shown to alter the timing of the critical period of plasticity in mouse visual cortex, establishing a causal relation between neurotrophin action, the development of visual function, and the duration of the critical period.
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