期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 65, 期 7, 页码 509-515出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2011.06.006
关键词
Salinomycin; Aldehyde dehydrogenase; Gastric cancer
资金
- National Natural Science Foundation of China [81172329, 30770961, 30973486]
- Chinese National High Tech Program [863-2006AA02A402, 2006AA02A301]
- Shanghai Science and Technology Commission [09DZ1950101, 09JC1409600]
- Shanghai Excellent Academic Leader Plan [11XD1403600]
Salinomycin is a novel identified cancer stem cells (CSCs) killer. Higher ALDH activity represents CSCs characterization. Here, we screened ALDH activities on several gastric cancer cell lines and divided them into ALDH(high) and ALDH(low) gastric cancer groups. ALDH(high) cancer cells (NCI-N87 and SNU-1) disclosed more CSCs characteristics, such as higher levels of Sox2, Nanog and Nestin, more floating spheroid bodies, more colony formation and more resistance to conventional chemotherapeutic drugs 5-Fu and CDDP, compared to these parameters observed in ALDH(low) cancer cells (P < 0.01). Importantly, ALDH(high) cancer cells are relatively sensitive to salinomycin when compared to ALDH(low) cancer cells (P < 0.01). Our results confirmed ALDH as functional marker of CSCs population on gastric cancer. Salinomycin might be selective therapy for CSCs fraction, which is resistant to conventional anticancer drugs 5-Fu and CDDP. (C) 2011 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据