期刊
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
卷 61, 期 2, 页码 119-123出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0169-2607(99)00033-4
关键词
clustered samples; binary data; correlation; intracluster
Clustered or correlated samples with binary data are frequently encountered in biomedical studies. The clustering may be due to repeated measurements of individuals over time or may be due to subsampling of the primary sampling units. Individuals in the same cluster tend to behave more alike than individuals who belong to different clusters. This exhibition of intracluster correlation decreases the amount of information about the effect of the intervention. In the analysis of randomized cluster trials one must adjust the variance of estimator of the mean for the effect of the positive intraclass correlation rho;. We review selected alternative methods to the typical Pearson's chi(2) analysis, illustrate these alternatives, and out line an alternative analysis algorithm. We have written and tested a FORTRAN program that produces the statistics outlined in this paper. The program is available in an executable format and is available from the author on request. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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