期刊
PHYTOCHEMISTRY
卷 53, 期 3, 页码 391-394出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(99)00513-0
关键词
Camellia sinensis; Theaceae; apoptosis; tea catechins; polyphenol structure
Several catechin compounds were examined for their ability to induce apoptosis in human hystiocytic lymphoma U937 cells. Catechins with a pyrogallol-type structure in a B-ring induced apoptosis and a 3-O-gallate group in cis-relationship to the B ring enhanced the activity. Catechins without a pyrogallol-type structure in a molecule lacked activity. These data suggest the important role of the 5'(3')-hydroxyl group in the B-ring and that a pyrogallol-type structure in a molecule is a minimum requirement for apoptosis induction by catechin compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.
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