期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 25, 期 2, 页码 64-70出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(99)01519-4
关键词
-
Recent studies have consolidated the pivotal role of Smads as intracellular effecters of TGF-beta family members. Upon binding to their specific type I and type II serine/threonine kinase receptors, each family member activates a particular subset of Smad proteins. Activated, receptor-regulated Smads form hetero-oligomeric complexes with common-partner Smads that translocate into the nucleus, where they control the expression of target genes in a cell-type-specific manner. Smads appear to function not only as nuclear effecters for TGF-beta family members, but as signal integrators within an extensive intracellular network.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据