期刊
JOURNAL OF ANTIBIOTICS
卷 53, 期 2, 页码 153-157出版社
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.53.153
关键词
-
The biosynthesis of cladospirone bisepoxide (1) was investigated by feeding C-13-labeled acetate to growing cultures of the fungus Sphaeropsidales sp. (strain F-24'707). C-13 NMR spectral analysis demonstrated the polyketide origin of both naphthalene units. The origin of two epoxide oxygens was confirmed as from air by cultivation of the strain in an O-18(2)-enriched atmosphere. The [O-18]incorporation pattern into palmarumycin C-12 (11), the putative precursor of 1 led to the hypothesis that the carbonyl oxygen of 1 is derived from water by exchange of an oxygen atom. inhibition of the biosynthesis of 1 with tricyclazole, an inhibitor of the 1,8-dihydroxynaphthalene (DHN) melanin biosynthesis, confirmed the connection of both biosynthetic pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据