期刊
IMMUNITY
卷 12, 期 2, 页码 151-160出版社
CELL PRESS
DOI: 10.1016/S1074-7613(00)80168-5
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- NCI NIH HHS [CA35299] Funding Source: Medline
- NIGMS NIH HHS [GM50819] Funding Source: Medline
Vav and PKC theta play an early and important role in the TCR/CD28-induced stimulation of MAP kinases and activation of the IL-2 gene. Vav is also essential for actin cytoskeleton reorganization and TCR capping. Here, we report that PKC theta function was selectively required in a Vav signaling pathway that mediates the TCR/CD28-induced activation of JNK and the IL-2 gene and the upregulation of CD69 expression. Vav also promoted PKC theta translocation from the cytosol to the membrane and cytoskeleton and induced its enzymatic activation in a CD3/CD28-initiated pathway that was dependent on Rac and on actin cytoskeleton reorganization. These findings reveal that the Vav/Rac pathway promotes the recruitment of PKC theta to the T cell synapse and its activation, essential processes for T cell activation and IL-2 production.
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