期刊
JOURNAL OF CELL BIOLOGY
卷 210, 期 6, 页码 871-882出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201507005
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- The Francis Crick Institute [10144, 10180] Funding Source: researchfish
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called S1K25 or SOK1). MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cancer, endothelial malformations, and autoimmune disease.
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